Endocrine Abstracts

Introduction: Polycystic ovarian syndrome (PCOs) is a common cause of ovarian dysfunction in women with anovulation. Vitamin D plays a physiologic role in reproduction including ovarian follicular development and luteinization via altering anti-müllerian hormone (AMH) signalling, follicle-stimulating hormone sensitivity and progesterone production in human granulosa cells. Low vitamin D levels may exacerbate the symptoms of PCOS, including insulin resistance, ovulatory, m...

When in September 1948 the ’Compound E’ was first synthesized and successfully administered as intramuscular injection to a woman with rheumatoid arthritis, hardly that anyone could imagine what profound impact it will have on medical research and practice. In a span of just two years, in 1950, the fascinate drug was renamed to Cortisone and brought from laboratory to broad clinical use. Seventy years later, it is still hard to find a medical field where corticostero...

We report a case of 39–year-old female presented with painful, scaling skin lesions on insulin application sites. She was diagnosed with type 1 diabetes mellitus (T1DM) at the age of 21 years and treated with intensified conventional insulin therapy. Three months before hospital admission, she suddenly started to feel pain at insulin injection sites, followed by oval subcutaneous deposits and skin ulcer in the further course. Identical local changes repeated after subcuta...

A 65–year-old male was referred to endocrinologist due to significantly elevated calcitonin level of 3662 pg/ml. Previously, almost 3 decades before, the patient underwent right thyroid lobectomy for papillary carcinoma. Then, 9 years afterwards, he was reoperated and total thyroidectomy with neck exploration was performed. In pathohistological finding, metastatic papillary carcinoma was proved. Radioactive iodine ablation was used as a post surgical treatment. After comp...

Introduction: Gestational diabetes(GDM) is a kind of diabetes that can happen during pregnancy. Many women who have GDM, get type 2 diabetes later in life. GDM is more likely for women who are overweight, women with family members who have type 2 diabetes and women who are American Indian. During pregnancy of healthy women, it is usual for blood lipids to increase significantly. Total cholesterol, HDL- and LDL-cholesterol increase 25-50%, triglycerides increase twice to four t...

Idiopathic short stature (ISS) is a condition characterized by a height more than 2 standard deviations below the corresponding average height for a given age, sex and population, without any identifiable systemic, endocrine, nutritional, or chromosomal disorder, and normal stimulated growth hormone (GH) levels. We report a case of a 17-years-old female, admitted to the hospital for endocrinology reevaluation. She was firsty reffered to endocrinologist for short stature at the...

Acromegaly is chronic disease caused by hypersecretion of growth hormone (GH), most common caused by adenoma of pituitary gland. Cardiovascular risk, respiratory complication and malignancy are more common in this patients. Most often onset is between 30 to 50 years old, equally between gender. Therapy is almost always surgery, it can be combined with radiotherapy and gamma knife. Medicament therapy with somatostatin analogues, dopamine agonists and GH receptor antagonist. Goa...

Objective: Diabetes mellitus is among the most common of chronic disorders with increasing prevalence worldwide, affecting 50 000 citizens in Montenegro. The insulin pump is a medical device that works on the principle of continuous insulin injection, and is used in the control of diabetes in insulin dependent patients. The objective of this study was to highlight the role of nurse in education of the patients, implantation of insulin pump and nursing networking for insulin pu...

Introduction: Juvenile dermatomyositis may be associated with advanced calcinosis but the mechanism that leads to their development remains unclear.Case report: A female patient admitted to the hospital at the age of 17 for skin rash, malaise and pain in peripheral joints and muscles. Congenital bilateral hip dysplasia. After evaluation a syndrome overlap with dominant atypical dermatomyositis and SLE was suspected and treatment with prednisolone and cho...

Background: Gaucher disease (GD) is the most common lysosomal storage disorder. The defect is deficiency of lysosomal glucocerebrosidase (GBA), due to biallelic mutations in GBA gene, characterized by the deposition of GBA in cells of the macrophage-monocyte system.Objective: To report clinical phenotypes of GD and correlate with GBA gene mutations, and to identify GBA gene mutation in patients diagnosed with GD in Montenegro.Metho...